Lead Discovery

Nuevolution conducts drug discovery in fully partner funded programs as well as collaborative projects. With the inherent effeicency of the Chemetics® platform we can maintain a high number of active programmes as well as having a fast turn-around time delivering pre-clinical leads in a very short time.

Chemetics®-driven lead discovery represent a brute force approach with significant power:

• Synthesis and screening of ultra-large, structurally diverse libraries at an unprecedented scale - upwards of 100 million small molecules - facilitating efficient identification of hundreds of highly diverse hit and lead molecules rather than just a few.

• The chance of finding hits and leads for challenging targets is greatly improved.

• The large number and diverse set of hits and leads generated offer an excellent starting point for lead optimization. Moreover, multi-million member focused libraries may be generated, with all hits optimized in parallel, ultimately leading to a more diverse set of high quality optimized leads and potential backup candidates.

• Through rapid generation of potent leads for a given target, it is possible to identify leads for several targets implicated in the same disease in parallel. The compound and target with the optimal therapeutic profile can then be selected for pre-clinical development.

• Finally, the ability to generate large focused libraries makes it possible to limit and tailor e.g the molecular weight and lipophilicity of compounds as they are progressed through the optimization process, thus optimizing chances of achieving optimal bioavailability.